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Ricerca Progetti Pubblicazioni Strutture Valorizzazione Evidenze La ricerca Mission e
Virtualizzazione delle cardiopatie per la salute e la cura del cuore 4.0 - VI.CURA 4.0
Home Progetti Finanziatori nazionali Virtualizzazione delle cardiopatie per la salute e la cura del cuore 4.0 - VI.CURA 4.0. Il progetto è sostenuto dal MISE – Ministero dello Sviluppo Economico (www.mise.gov.it) (AI SENSI DEL DECRETO DEL MINISTRO DELLO SVILUPPO ECONOMICO 5 MARZO 2018 – CAPO II). https://vicura.it/ https://vicura.eu Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Massimo Massetti - Gianluca Castelnuovo Periodo di svolgimento della ricerca: 2021 - 2024 #malattie cardiovascolari #modelli 3d #cuore #virtualizzazione #cardiopatie #stampa 3d.
Integrazione sanitaria della popolazione Rom e Sinta
Home Progetti Finanziatori nazionali Integrazione sanitaria della popolazione Rom e Sinta. Inoltre, mediante la sperimentazione di meccanismi di prevenzione concreti ed efficaci per fronteggiare situazioni critiche in campo epidemiologico e infettivologico, sono stati effettuati interventi rivolti a soggetti contraddistinti da particolari vulnerabilità economiche, sociali e mediche. Le attività condotte hanno beneficiato, così come previsto dalla Raccomandazione del 12 marzo 2021 del Consiglio dell'UE (2021/C 93/01) e dalla Strategia Nazionale di Uguaglianza, Inclusione e Partecipazione di Rom e Sinti (2021-2030), del coinvolgimento dei referenti delle comunità Rom e Sinte nelle attività di programmazione e implementazione del progetto. https://www.infosaluteromesinti.it/ Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Umberto Moscato Periodo di svolgimento della ricerca: 2025 - 2028 #contrasto alla discriminazione #accesso ai servizi socio-sanitari.
Home Progetti Finanziatori nazionali Software prediction of aggressive/suicidal behaviors based on clinical, neuroimaging and motion/facial expression data through Artificial Intelligence (PRED-AGGR). Software prediction of aggressive/suicidal behaviors based on clinical, neuroimaging and motion/facial expression data through Artificial Intelligence (PRED-AGGR) Roma, 2025 - 2029 Background Aggressive behaviors in psychiatry represent a fundamental health problem that impact patients' and caregivers' lives, as well as the whole social system. It refers primarily to two different types of aggressive behaviors: towards others; and towards themselves (suicidal behaviors). Interestingly, current advances in the field have focused on the need for more precise neuroimaging biomarkers for aggressive and suicidal behaviors. Specifically, converging evidences found brain structural abnormalities in cortical and subcortical volumes in patients presenting with aggressive and suicidal behaviors. These data, together with automated system for identifying human emotions from facial expressions, may contribute to an early identification of aggressive and suicidal behaviors. Working group Dott.ssa Delfina Janiri - Responsabile scientifico UCSC Prof.ssa Simona Gaudino Prof. Gabriele Sani Prof. Marco De Spirito Prof.ssa Silvia Giovannini Prof.ssa Daniela Pia Rosaria Chieffo Prof. Giuseppe Maulucci Prof. Luca Indovina Prof.ssa Silvia Giovannini Dott.
Platform Level Bureaucracy and Social Inclusion - PERSON
Home Progetti Finanziatori nazionali Platform Level Bureaucracy and Social Inclusion - PERSON. Platform Level Bureaucracy and Social Inclusion - PERSON Milano, 2025 - 2028 PNRR per la Missione 4, Componente 2, Investimento 1.2 - D.D.201 del 03/07/2024 - codice progetto SOE2024_0000096 - CUP J43C24000910006 - Finanziato dall'Unione europea Next Generation EU PERSON analyses changes in the bureaucratic encounter and in the discretion of street-level bureaucrats (SLBs) when access to services becomes digital. By studying the use of the unemployment application platforms DID online, PERSON investigates how digital bureaucratic encounters influence the discretion of SLBs, and aims to develop guidelines for inclusive public platform design, overcoming barriers related to gender, age, disability and ethnicity. Sicily, on the other hand, is distinguished by lower levels of digitalization of its ppublic administration: the regional Cabinet for Digital Public Administration was set up to begin digitising services only in 2023. As the DID online unemployment application can be managed either within the National MyAnpal platform or within individual regional portals, the differences between the involved regions’ portals will also be considered. At a methodological level, creative tools for digital qualitative research (such as Digital Subsystem Technique and Vignette Technique for Internet Based Research) will be developed and used, under the supervision of an international advisory board of experts in SLB theory, digital innovation and comparative research. The final objective is to develop guidelines for an inclusive platform for the public sector: the design phase will be carried out with the participation of associations active on the local territories (e.g. Labas Bologna, Non Una di Meno, AFADI Palermo).
Promuovere Risorse Individuali e Sociali nel Mondo Accademico – Università per il benessere (PRISMA)
Home Progetti Finanziatori nazionali Promuovere Risorse Individuali e Sociali nel Mondo Accademico – Università per il benessere (PRISMA). Promuovere Risorse Individuali e Sociali nel Mondo Accademico – Università per il benessere (PRISMA) Milano, 2024 - 2025 CUP Master F53C24000430001, CUP UOL J53C24001610001, Spesa finanziata con il contributo del Ministero dell’Università e della ricerca ai sensi dell’avviso D.D. c) La realizzazione di iniziative e di spazi prettamente dedicati alla sensibilizzazione e alla formazione sui temi oggetto del bando, rivolti a tutte le componenti delle singole comunità accademiche, del territorio e della rete PRISMA. d) L’identificazione e l’adozione di strumenti specifici volti ad ampliare e ottimizzare i SCPA (servizi di counseling psicologico di Ateneo e AFAM), anche attraverso lo scambio e la formazione inter-Ateneo/AFAM degli specialisti. Tutti gli obiettivi individuati sono funzionali a promuovere le risorse di studenti e studentesse e i fattori protettivi per poter contrastare l’insorgenza di condizioni di rischio con particolare attenzione al fenomeno delle dipendenze a diversi livelli di compromissione del funzionamento della personalità. La varietà di appartenenza territoriale degli enti coinvolti, provenienti da diverse regioni e città, favorirà la diffusione interregionale di buone pratiche permettendo, inoltre, un confronto analitico preciso tra i dati, anche su base geografica.
Mitochondria as a novel therapeutic target in Fragile X-related disorders
Home Progetti Finanziatori nazionali Mitochondria as a novel therapeutic target in Fragile X-related disorders. Mitochondria as a novel therapeutic target in Fragile X-related disorders Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. In Alzheimer's, Parkinson's, Huntington's diseases and amyotrophic lateral sclerosis, the role of mitochondria in neurodegeneration has been established, supporting the hypothesis that mitochondrial impairment has a critical role in the neurodegenerative process. Full mutation (FM, >;200 CGGs) alleles become methylated, resulting in FMR1 silencing and hence in Fragile X syndrome (FXS, OMIM#300624), a neurodevelopmental disorder affecting learning and behaviour. There exist rare alleles with a FM completely unmethylated (UFM), thus preventing to develop FXS. The FMRP protein, which is absent in FXS and downregulated in PM and UFM, is an RNA-binding protein involved in several aspects of RNA metabolism particularly in brain. We found high levels of the superoxide dismutase 2 enzyme, associated with atypical mitochondrial morphology, in PM and UFM cells and published these results thanks to our previous PRIN project (Prot. Our data show that mitochondrial proteins involved in OXPHOS and the cyclophilin D (CypD), a known modulator of the permeability transition pore (PTP) inducing apoptosis, are upregulated in fibroblasts derived from FXS, PM and UFM patients.
The SKOPE Study. SeeKing the Origins of PreEclampsia: from endometrial to placental perspectives
SeeKing the Origins of PreEclampsia: from endometrial to placental perspectives. SeeKing the Origins of PreEclampsia: from endometrial to placental perspectives Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. In normal human placentation, uterine invasion by trophoblast cells and subsequent spiral artery remodeling depend on the cooperation between fetal trophoblasts and maternal decidual, myometrial, immune, and vascular cells of the uterine wall. Aim of this project is to test the hypothesis that decidualization failure contributes to the pathogenesis of PE and investigate which dysregulated molecular pathways are involved in the development of decidualization resistance. The role of maternal endometrium in decidualization failure will be investigated using endometrial stromal cells isolated from non-pregnant women with either a previous history of EO-PE or experiencing recurrent pregnancy loss (RPL) and compared with control women with previous uncomplicated pregnancy. The use of endometrial tissue from both EO-PE and RPL is justified by the fact that women experiencing RPL have a higher risk of developing PE, suggesting that PE and RPL share pathogenic factors. Finally, samples of placental decidua (basalis and parietalis) will be collected at the time of delivery from women with PE and women with uncomplicated pregnancy and used to confirm whether alterations observed in the non-pregnant decidual tissue persist and progress during pregnancy.
Home Progetti Finanziatori nazionali The Interplay between Psychosocial Mechanisms, T cell functionality and Microbiota in BRCA1/2 on cancer progression in High-Risk Patients. The Interplay between Psychosocial Mechanisms, T cell functionality and Microbiota in BRCA1/2 on cancer progression in High-Risk Patients Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. Although only 5-10% of BC bears harmful mutations in the DNA damage repair genes BReast CAncer (BRCA) 1 and 2; women with BRCA1/2 mutations have higher risk of developing BC and 40-65% of them will encounter the disease by the age of 70. The present project aims to explore the predictive role of psychological variables on cancer progression and immune functions in BRCA1/2 high-risk BC population. Consistently, the main aim of the ImmuneMind project is to develop a predictive model of the impact of psychological, social and clinical variables on T cell functionality and microbiota in BRCA1/2 mutation carriers. Results from this project will shed light on the multi-facet mechanisms that affect the somatic environment, profiling quantitatively the influence of psychological variables and personal characteristics on the function of the immune system and on gut microbiota. Results will help reconcile previous observations while providing evidence of the potential benefits of psychological interventions on ameliorating clinical outcome in BRCA1/2 high-risk BC patients.
Home Progetti Finanziatori nazionali The pro-inflammatory activity of the p75NTR/proNGF axis as a novel target for the treatment of patients with chronic arthritis. The pro-inflammatory activity of the p75NTR/proNGF axis as a novel target for the treatment of patients with chronic arthritis Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. The goal of this project is to fill this void demonstrating the novel pathogenic role of proNGF/p75NTR axis in chronic arthritis and how its activation affects the functions of the cell types involved in joint inflammation. Our hypothesis, based on previous results and many preliminary data on RA and JIA patients and an arthritis animal model, is that the activation of proNGF/p75NTR axis enhances pro-inflammatory mediator production contributing to the chronicity of inflammation. We will investigate also if dysregulation of proNGF/p75NTR axis is a biomarker of disease severity and predictor of response to treatments in pediatric and adult chronic arthritis patients. Subsequently, the studies in vitro will define, in purified cell populations involved in arthritis pathogenesis, how the identified regulatory networks and epigenetic mechanisms involving microRNAs and alarmins are modified by activation of p75NTR/proNGF axis and by p75NTR inhibition, and whether they reinforce this axis. The effects of p75NTR inhibition on the inflammatory response will be then verified in vivo, in animal arthritis models, by analyzing inflammatory infiltrate, cytokine production and effector mechanisms leading to cartilage and bone degradation.
Home Progetti Finanziatori nazionali Innovative PET tracers for the early diagnosis of CNS neurodegenerative disorders: radiosynthesis of P-gp selective inhibitors as new potential theranostics. Innovative PET tracers for the early diagnosis of CNS neurodegenerative disorders: radiosynthesis of P-gp selective inhibitors as new potential theranostics Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. However, the low brain uptake of radiotracers used in these studies, raised concerns on their capability of detecting P-gp activity variation, especially P-gp hyperactivity. MC225 demonstrated higher brain uptake at baseline conditions as compared to other P-gp radiotracers thus surging as a reliable and sensitive marker of P-gp hyperactivity. Starting from these promising results, the aim of the present project is to design P-gp inhibitors, since [18F]MC225 is a P-gp substrate, in order to deepen the P-gp role at BBB in CNS diseases. To date, potent and selective P-gp inhibitors are not available because tariquidar, the most studied P-gp radiotracer, is a dual P-gp/BCRP ligand. We have preliminarly designed and tested two ligand, MC18, the first potent and selective P-gp inhibitor, that has been 11C radiolabeled, and MC70, the most potent P-gp inhibitor, that is used as tool as commercially available, bearing an useful group to develop 18F radiolabeleled derivative.
Home Progetti Finanziatori nazionali Role of the IBD-associated OCTN1/Slc22A4 solute carrier in bacterial sensing and microbe-host interaction. Role of the IBD-associated OCTN1/Slc22A4 solute carrier in bacterial sensing and microbe-host interaction Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. The L503F (1672t) allele of the organic cation transporter novel 1 OCTN1/Slc22A4 has been linked to Inflammatory Bowel Disease (IBD) and more recently to colitis-associated cancer, but evidence for this gene variant being disease causal, and the mechanistic underpinnings, have remained elusive. Accordingly, our preliminary data show that monocytes from healthy carriers of the 503F variant display an enhanced Interleukin 1 beta response to the bacterial wall component peptidoglycan (PGN) compared to control subjects; moreover, OCTN1 forms a complex with NOD2, an immune receptor for PGN fragments. We’ll use a combination of biomolecular, microbiological and confocal imaging studies to address how OCTN1 genotype and expression level affect cytokine responses and microbial killing in monocytes exposed to MAMPs, or infected with selected bacterial strains. Searching for a molecular link between OCTN1 and specific immune cascades, we’ll also evaluate OCTN1's physical interaction with the bacterial sensor NOD2 and other intracellular immune receptors. b) To identify novel bacterial substrates for OCTN1 in PGN hydrolysates or bacteria-conditioned supernatants by a novel methodology based on substrate trapping in artificial proteoliposomes followed by Mass Specrometry identification.
Housing Deprivation, Urban Poverty and Development - HOUSINGDEP
Home Progetti Finanziatori nazionali Housing Deprivation, Urban Poverty and Development - HOUSINGDEP. Housing Deprivation, Urban Poverty and Development - HOUSINGDEP Milano, 2025 - 2028 Homelessness and precarious living conditions, such as slums and informal settlements, have recently emerged as critical issues among the urban poor, garnering significant attention from policymakers worldwide. The consequences of housing instability are dramatic, affecting both individual well-being (including skill deterioration and reduced human capital accumulation) and society at large (contributing to decreased labor force participation and higher crime rates), thus perpetuating the vicious circle of poverty. Yet we know remarkably little on the specific factors leading to homelessness and housing instability, as well as on effective policies to foster positive behaviors among homeless individuals and children living in precarious housing. I will then design a rigorous evaluation to address physical (i.e. distribution of lockers) and mental barriers (i.e. mentoring programs) among the homeless (Project 2). To address the second question, I will design and carry out two randomized control trials aimed at improving educational attainment of children living in Brazilian favelas (Project 3) and displaced children due to terrorist attacks in Burkina Faso (Project 4). This research adds several innovative aspects to an understudied area in economics: (i) novel survey methodologies for studying highly mobile populations; ii) original data collected through survey work in challenging contexts; (ii) rigorous evaluation methods to limit the consequences of housing deprivation.
Dravet's syndrome rating scale: validation of a tailored tool for neuromotor assessment
Home Progetti Finanziatori nazionali Dravet's syndrome rating scale: validation of a tailored tool for neuromotor assessment. Dravet's syndrome rating scale: validation of a tailored tool for neuromotor assessment Roma, 2025 - 2027 PRIN 2022 Scorrimento - Prot. CUP J53C2400305000 Dravet Syndrome (DS) is the most prevalent genetic developmental and epileptic encephalopathy, characterized by drug-resistant seizures, cognitive, behavioral, and motor impairment. Motor features of DS have been less clearly characterized but were repeatedly strongly associated with cognitive performance and quality of life, similarly to what is seen in ageing and neurodegenerative disorders. We will assess motor features of patients with DS of different ages, studying both motor function and movement disorders. We expect this study to have a significant impact on the quality of life of patients by increasing the emphasis on motor function in DS both as a direct measure of ability and independence and as an indirect measure of cognitive and behavioral comorbidities. Working group : Domenica Immacolata Battaglia - Responsabile scientifico UCSC Partners : Università di Pisa Procedure di selezione : Procedure chiuse: BANDO 679_2025_Battaglia_PRIN 2022 Scorrimento - prot.
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Home Strutture Dipartimenti e istituti Piacenza-Cremona Piacenza-Cremona Economia agro-alimentare Scienze animali, della nutrizione e degli alimenti Scienze delle Produzioni Vegetali Sostenibili Scienze e Tecnologie Alimentari per una filiera agro-alimentare Sostenibile Scienze economiche e sociali Scienze giuridiche.
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Home Structures Departments and Institutes Piacenza-Cremona Piacenza-Cremona Agricultural and Food Economics Animal, Nutrition and Food Sciences Sustainable Crop Production Sustainable Food Process Economic and Social Sciences Legal Sciences.
Human-Robot Confluence: towards a multimodal analysis of human-robot interactions
Human-Robot Confluence: towards a multimodal analysis of human-robot interactions Milano, 2018 - 2021 Le dinamiche sociali che si instaurano con i robot verrebbero analizzate a tre livelli: L'interazione prossimale uomo-robot : Una prima dimensione di analisi riguarda l'interazione tra uomo e robot nel contesto di un'attività motoria condivisa. I robot di nuova generazione percepiscono le caratteristiche fisiche dell'ambiente che li circondano e che negoziano l'uso delle risorse presenti nello spazio con altri oggetti, robot, o con gli esseri umani. Dal punto di vista della ricerca scientifica, l'interazione uomo- robot è caratterizzata da comportamenti dinamici che si modificano in relazione alle condizioni ambientali che via via si creano. Una ragione è senza dubbio legata alla fisicità, e la tangibilità dei robot autonomi che funzionano da catalizzatori dell'interazione e creano quel particolare fenomeno per cui l'essere umano tende ad antropomorfizzare i robot. Tuttavia, come evidenziato dal fenomeno dell'"Uncanny valley", rimane un certo livello di disagio emotivo nell'interazione con i robot che limita il coinvolgimento umano nell'interazione, riducendo il livello di "presenza" dei robot. Tuttavia, a differenza di questi ultimi la capacità di prendere decisioni nei robot assume una caratteristica particolare se combinata con quella di relazionarsi con l'ambiente e di negoziare l'uso delle risorse a disposizione in modo dinamico. Da questo punto di vista i robot di nuova generazione rappresentano una piattaforma con cui studiare la teoria della mente e il processo di "trust".
