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EUVAC Roma, 2024 - 2027 The European Digital Vaccination Card (EUVAC) is crafted in MyHealth@EU services as a self-contained document, empowering individuals to monitor their vaccination histories. Operating as a technical exchange format or pivotal platform, the EUVAC streamlines the transfer of vaccination records across diverse information systems which is fundamental for the development of interoperable vaccination card functionalities by Member States. It allows citizens to effortlessly store and oversee their vaccination data, which they can then be presented to health professionals during in-person consultations. The European digital vaccination card (EUVAC) ensures the sustained continuity of care by being enduring over time and portable. This signifies that vaccination data can be shared, whether within local or remote, public or private repositories, moving seamlessly from one physical or virtual location to another. Crucially, this process is initiated and overseen by the citizens, granting them autonomy over their health information and ensuring the secure and effective management of vaccination records. Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Fidelia Cascini Periodo di svolgimento della ricerca: 2024 - 2027 #digital vaccination card #myhealth@eu #cross-border e-health services.
Home Progetti Finanziatori UE Joint Actions.
Xt-EHR Roma, 2023 - 2026 The Xt-EHR joint action supports the Commission’s policy priority for “A Europe fit for the digital age” by implementing the EU4Health Programme’s general objective of “strengthening health systems”. More specifically, the Xt-EHR proposal will prepare implementation guides, technical specifications, and a conformity assessment framework for the adoption of the European Electronic Health Record Exchange Format (EEHRxF), at a European Level. Evaluate telemedicine, mobile health, and other health software in the context of the EEHRxF and the EHDS Regulation proposal. Evaluate common EHR requirements for electronic identification for health professionals and patients (based on the European Digital Identity framework), and the necessary metadata layer needed. Through Xt-EHR, the interoperability and cross-border exchange of different types of health data will be promoted by proposing the necessary implementation guidelines for the implementation of new services that will complement the MyHealth@EU initiative. The necessary integration profiles of EHRs in the European market will be defined for improving the coordination of MS joint efforts towards interoperability in the EHDS proposal for primary use of health data. https://www.xt-ehr.eu/ Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Fidelia Cascini Periodo di svolgimento della ricerca: 2023 - 2026 #ehds #ehr #ehealth #myhealth@eu #ncpeh #cross-border health #patient access #interoperability #fhir #ihe.
PERCH Roma, 2022 - 2025 Human papillomavirus (HPV) is a DNA virus that consists of more than 100 subtypes, of which more than 40 are sexually transmitted and can infect anogenital and oropharyngeal mucosa. At least 14 HPV types classified as ‘high risk’ can cause cervical cancer in women, and a fraction of other anogenital cancers and head and neck cancers in both genders. In 2020, according to data from the Global Cancer Observatory (CGO), cervical cancer was the 4th most common cancer among women worldwide. Cervical cancer is a highly preventable disease through HPV vaccination (primary prevention) and cervical cancer screening (secondary prevention), and is a treatable disease if detected promptly and properly treated. In order to achieve the 90% HPV vaccination coverage goal set up by the WHO, many countries require actions to improve their specific vaccination coverages. To this aim, determinants of vaccination hesitancy will be analyzed in order to increase knowledge and awareness among the target population, and training activities will be set up for healthcare personnel on vaccination communication. https://www.projectperch.eu/ Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Stefania Boccia Periodo di svolgimento della ricerca: 2022 - 2025 #hpv #human papilloma virus #.
Home Progetti Finanziatori UE JA PreventNCD. JA PreventNCD Roma, 2024 - 2027 Cancer and other NCDs (C&;NCD) make up more than 2/3 of the burden of disease in Europe. At the population level, substantial variations exist according to socio-economic status, geographical area, age, disability, gender, and ethnic groups. A large part of this disease burden is preventable. This JA represents an ambitious effort to provide strategic guidance and consolidated efforts to the field of C&;NCD prevention. Key outputs include an EU Consortium on Cancer Prevention, high-level annual events, and intervention tools and policy recommendations that will contribute to reduced C&;NCD burden and inequality across Europe. https://preventncd.eu/ Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Roberta Pastorino Periodo di svolgimento della ricerca: 2024 - 2027 #health promotion #non communicable diseases #prevention #cancer #.
TEHDAS2 Roma, 2024 - 2027 The European Health Data Space aims to harmonise the secondary use of health data by creating a common legal framework. The main aim of the joint action is to prepare ground for harmonised implementation of the EHDS on secondary use of health data and develop collaboration between all key stakeholders. TEHDAS2 will provide 20 guidelines and technical specifications which will guide Member States and the Commission in developing solutions and operationalising cross-border collaboration. TEHDAS2 results will guide the Health Data Access Bodies in their future tasks and obligations, as well as data holders and users in fulfilling their forthcoming duties in the proposed regulation. The results will address, inter alia, the discovery and description of datasets; advancing access to health data by key players along the health data lifecycle; a technical framework for secure processing environments; involving citizens; and creating operational and collaboration models for the common policies. TEHDAS2 builds on earlier projects, in particular the first Joint Action Towards the European Health Data Space (TEHDAS) and HealthData@EU, and it will work closely with relevant ongoing projects and initiatives to create complementarities and synergies. https://tehdas.eu/ Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Fidelia Cascini Periodo di svolgimento della ricerca: 2024 - 2027 #health data #health data space #ehds #data space #secondary use of health data #reuse of health data #health data sharing #data sharing.
HEROES Roma, 2023 - 2026 The current pandemic has taught us that HEROES should not be sought in movies, but rather in those professionals who work in healthcare organizations daily. Part of their priceless merit is due to the fact that they must frequently face highly challenging scenarios in a situation of under-staffing. The HEROES Joint Action is aimed at improving the HWF planning capacities of European countries so to ensure accessibility, sustainability, and resilience of healthcare services. The JA addresses three main objectives: 1) to improve databases used in HWF planning; 2) to develop effective tools and methods to carry out HWF planning; 3) to define the best skill-mix needed by professionals to carry out HWF planning. For each of the three objectives, clusters will perform and “as is” analysis and define a desirable “to be” scenario at the Member State level. These will be able to benchmark their national HWF planning strategy with international experiences and adapt in consequently. https://healthworkforce.eu/ Sede: Roma Area Scientifica: scienze economiche e statistiche Responsabile scientifico: Irene Gabutti Periodo di svolgimento della ricerca: 2023 - 2026 #health workforce #.
GHI Roma, 2023 - 2025 The European Union (EU)'s leadership has played a key role in the fight against the COVID-19 pandemic globally through the Team Europe approach, with the EU and Member States (MS) acting within their respective competences. In the context of the implementation of the new EU Global Health Strategy, better coordination to strengthen this leadership and its visibility is essential to maximize the collective impact of such EU contributions to global health and to shape a new global health order based on our fundamental values. A comprehensive communication plan will be developed to strengthen its external communication so that the contributions of the EU and its Member States to global health are well acknowledged and understood. The Team Europe approach will be promoted as a brand for EU action in global health. Finally, a Member States' suggestions forum will be organised to anticipate and discuss important topics to support the EU positioning on such topics ahead of key GH meetings (WHO, G7, G20, etc.).
EU CanScreen Roma, 2024 - 2028 The Europe’s Beating Cancer Plan has called for a new EU-Supported Cancer Screening Scheme to assure high performance of cancer screening programs across all the Member States (MS). The general objective of EUCanScreen is to assure sustainable implementation of high-quality screening for breast, cervical and colorectal cancer as well as implementation of the recently recommended screening programs – for lung, prostate and gastric cancers. The work-plan of EUCanScreen has been built on the results of previous and ongoing major EU activities in screening; it is designed within eleven closely interlinked work-packages. Overall budget is 38.749.935,32 EUR. https://www.dypede.gr/eucanscreen/ The consortium brings together 29 countries, including 25 EU Member States, Ukraine, Moldova, Norway, and Iceland. NARODOWY INSTYTUT ONKOLOGII IM. MARII SKLODOWSKIEJ-CURIE - PANSTWOWY INSTYTUT BADAWCZY (PL) 23. LIETUVOS SVEITAKOS MOKSLU UNIVERSITETO LIGONINE KAUNO KLINIKOS (LT) 42. FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA (ES) 56.
Ricerca Progetti Pubblicazioni Strutture Valorizzazione Evidenze La ricerca Mission e
Home Progetti Finanziatori nazionali Finanziatori nazionali Seleziona Carica gli altri.
Home Progetti Finanziatori nazionali Community identity between museum, great decoration in a public buildings and the city: sources, projects, collections, iconographic themes and strategies for self-rappresentation in the nineteenth and twentith centuries. The focus will be on the strategies of self-representation of urban communities between 19th and 20th Century, based on the case-studies of a few selected cities (Milan, Naples, Padua, Verona, Brescia, Bergamo, and Venice), seen as spaces for the experimentation of research methods and the application of specific cultural tools. The research will consider the phenomenon of displaying as it has been manifested inside and outside of the museums, and in the places of public gathering, in an attempt to comprehend and compare strategies and meanings adopted by communities to communicate their aesthetic, historical, social, political, and cultural image. The proposed chronology covers the period from the broad transformations of the latter half of the 19th Century to the present: it will be studied through archive research, inquiry on visual documents, the analysis of guides, journals, and various publications, including the most recent visual and multimedia sources. The Verona and Padua units will focus primarily on the city as widespread museum, as the place of self-representation of both new and old identities, in a critical period like that between the 19th and 20th Century. The core of their research will be the analysis of those artistic enterprises that shaped the visual identity of some cities in Veneto and Lombardy, creating new cultural, social, and political forms of identity-projection. Sede: Milano Area Scientifica: scienze dell’antichità, filologico-letterarie e storico-artistiche Responsabile scientifico: Prof. Alessandro Rovetta Periodo di svolgimento della ricerca: 2020 - 2023 #urban studies #museology #landscape drawing #cultural heritage #social identity #prin #faculty of arts and philosophy #.
Home Progetti Finanziatori nazionali Identification and characterization of novel antitumoral/antimicrobial insect-derived peptides: a multidisciplinary, integrated approach from in silico to in vivo. Identification and characterization of novel antitumoral/antimicrobial insect-derived peptides: a multidisciplinary, integrated approach from in silico to in vivo Roma, 2019 - 2023 Resistance to chemotherapy represents the major cause of treatment failure in cancer patients. Antimicrobial peptides (AMPs) are small molecules produced by all organisms and are attractive candidates for the design of new antimicrobial agents because of their efficacy and a low propensity for the development of resistance. The present research project proposes the production, by chemical synthesis and recombinant methodologies, the characterization of the mechanism of action and the evaluation of antimicrobial and antitumor activity of different peptides derived from the insect H. illucens. This research project will use an integrated approach comprising in-silico screening as well as fine molecular, functional and pharmacological characterizations and a series of in vitro/in vivo tests, to identify novel insect-derived antimicrobial and/or antitumor peptides. Partner : Università Cattolica del Sacro Cuore (Coordinator); Università degli Studi della Basilicata; Università degli Studi di Napoli Federico II; Università degli Studi di Roma "La Sapienza"; Università degli Studi di Catania. Sede: Roma Area Scientifica: scienze mediche Responsabile scientifico: Prof. Alessandro Sgambato Periodo di svolgimento della ricerca: 2019 - 2023 #drug discovery #chemistry of natural products #cancer #antibiotic resistance #proteomics #integrated approach #faculty of medicine and surgery.
Petrarca on-line: biography, works, library
Home Progetti Finanziatori nazionali Petrarca on-line: biography, works, library. At the same time, however, such technology cannot be perfectly controlled or trustworthy, a fact that can condition the methodological procedures of textual and literary criticism. In order to deal with this problem, the scientific community has tried to take the necessary precautions, beginning by directly observing, controlling and managing the potential of, and the materials offered by, Internet. Among this wealth of information, however, is notable the absence of a scientifically based website dealing exclusively with the life and works of Francesco Petrarch. The bilingual (Italian and English) website will take the form of a freely accessible and interactive platform , with digital resources deriving from ecdotic, philological, codicological-palaeographical and literary-critical research. Working group: Carla Maria Monti - Faculty of Arts and Philosophy Simona Gavinelli - Faculty of Arts and Philosophy Partner: Università Cattolica del Sacro Cuore (Coordinator); Università degli Studi di Messina; Università degli Studi “G. d’Annunzio” Chieti-Pescara; Università degli Studi di Bologna. Sede: Milano Area Scientifica: scienze dell’antichità, filologico-letterarie e storico-artistiche Responsabile scientifico: Prof. Marco Petoletti Periodo di svolgimento della ricerca: 2020 - 2023 #medieval italian literature #humanistic philology #italian literature #petrarca #faculty of arts and philosophy.
Modulation of EGFR signalling by cross-talk with other membrane receptor pathways
Home Progetti Finanziatori nazionali Modulation of EGFR signalling by cross-talk with other membrane receptor pathways. Modulation of EGFR signalling by cross-talk with other membrane receptor pathways Roma, 2019 - 2023 Epidermal Growth Factor Receptor (EGFR) is a cell surface protein with tyrosine kinase activity, and a major effector of extracellular signals promoting cell growth and survival, as well as tissue differentiation and homeostasis. EGFR is also considered a proto-oncogene, since its aberrant/constitutive activation is responsible for cancer cell growth and invasive properties; furthermore, its upregulation leads to resistance to targeted therapies in human solid tumors. Prompted by these preliminary data, in this project we aim at elucidating novel mechanisms regulating EGFR signaling, via the cross-talk with other membrane receptor pathways, such as inflammatory cytokines, or the Neuropilins and their extracellular ligands, including circulating miRNAs. Notably, secreted miRNAs circulating in body fluids may be captured and internalized by cell surface receptors, such as NRP1, and we will study whether such mechanism can effectively regulate mRNA transcripts encoding EGFR or other components of this pathway. Moreover, since NRP1 and NRP2 cell surface receptors have been found to regulate EGFR expression and signaling, their combined targeting with inhibitors and extracellular ligands could improve the efficacy of EGFR inhibitors in cancer treatment and prevent the onset of drug-resistance, as recently validated in our preliminary studies. In sum, we aim at the characterization of novel mechanisms controlling the EGFR pathway, via the cross-talk with other membrane receptors and their extracellular ligands.
Il suo obiettivo è quello di contribuire a incrementare la conoscenza e la discussione in merito a un livello di annotazione metalinguistica che trova poco spazio nelle ricerche sulle risorse linguistiche e sulla trattazione automatica del linguaggio applicate al latino. Il progetto prevede due fasi operative : Nella prima fase, si delineano le linee guida dell'annotazione, si individua lo strumento di annotazione e si procede con l'annotazione dei testi latini selezionati. Vengono utilizzati testi latini già arricchiti con lemmatizzazione e Part-of-Speech (PoS)-tagging e collegati alla LiLa Knowledge Base , una raccolta di molteplici risorse linguistiche per il latino descritte con lo stesso vocabolario di conoscenza e interconnesse secondo i principi del paradigma Linked Data ( https://lila-erc.eu/#page-top ). Segue l'elenco dei corpora dei testi che si prevede di arricchire con l'annotazione di coreferenza nell'ambito di questo progetto: Latino classico . I dati sono tratti dal corpus LASLA ( http://web.philo.ulg.ac.be/lasla/textes-latins-traites/ ), un'ampia raccolta di circa 1,7 milioni di parole provenienti da oltre 130 testi classici e tardo-latini lemmatizzati e contrassegnati morfologicamente. I dati di partenza sono stati resi liberamente disponibili sul repository del laboratorio LASLA prima dell'inizio di questo progetto e sono accessibili attraverso la LiLa Knowledge Base all'indirizzo https://lila-erc.eu/data/corpora/Lasla/id/corpus . I dati sono tratti dal corpus Computational Historical Semantics Corpus ( http://lila-erc.eu/data/corpora/CompHistSem/id/corpus ), un progetto cooperativo che coinvolge le università di Bielefeld, Francoforte, Ratisbona e Tubinga.
Home Progetti Finanziatori nazionali Textual Data and Tools for Coreference Resolution of Latin Data Data.
Ricerca Progetti Pubblicazioni Strutture Valorizzazione Evidenze La ricerca Mission e
Cultures of sovereignty, transformations of democracy and dynamics of power in the global age
Home Progetti Finanziatori nazionali Cultures of sovereignty, transformations of democracy and dynamics of power in the global age. Cultures of sovereignty, transformations of democracy and dynamics of power in the global age Milano, 2020 - 2023 During the last three decades in the human and social sciences, the processes identified as «globalization» has often been considered as the main cause of the crisis of the «sovereignty». Regardless of the results to which they came, many readings dedicated to the role of states, to their crisis or their survival, tend to proceed from a ‘monolithic’ view of «sovereignty», predominantly built on the model of the modern European state. In this sense, it would be essential to recognize different «cultures» of sovereignty, so like certain representations of reality, internalized (in different levels) by the actors, who establish criteria with which states interpret the international community and their own ‘material’ interests, and from which specific behaviors arise. The present research project intends to move within this image of sovereignty , with the aim of reconstructing the transformations in the cultures of sovereignty. Gruppo di lavoro: Silvio Cotellessa - Faculty of Political and Social Sciences Chiara Continisio - Faculty of Education Luca Pietro Azzaro - Faculty of Political and Social Sciences Partner: Università Cattolica del Sacro Cuore (Coordinator); Università degli Studi di Padova; Università degli Studi di Bologna; Università degli Studi di Salerno. Sede: Milano Area Scientifica: scienze politiche e sociali Responsabile scientifico: Prof. Damiano Palano Periodo di svolgimento della ricerca: 2020 - 2023 #sovereignty #governance #democracy #state #power #governmentality #prin #faculty of political and social sciences.
Home Progetti Finanziatori nazionali Textual Data and Tools for Coreference Resolution of Latin People People Unità Milano - Univerità Cattolica del Sacro Cuore Prof. Marco Carlo Passarotti (Principal Investigator) Dott. Paolo Ruffolo Dott.ssa Roberta Grazia Leotta Unità Udine - Università degli Studi di Udine Prof. Renato Oniga Dott.ssa Eleonora Delfino.
Winter pruning impacts for the 20-35% of the yearly labor demand that can be lowered by introducing mechanical operations when spur-pruning is adopted. Despite agricultural solutions have been developed in recent years, robotics in viticulture is still bursting, and only a few prototypes have been described for performing winter spur-pruning; at present engineering processes seem to be ongoing whilst interactions with grapevine physiology were never assessed. The first action will provide hierarchical guidelines for a translation of the human cognition process into algorithms for automated plant recognition, and robotized pruning. Multiple combinations of integrated general rules driving winter pruning process with specifically conceived case studies will compose a dedicated database for developing multi-modal sensing system for recognition of grapevine architecture and identification of target regions and cutting points. The second action will integrate off-the-shelf electric shears into a commercial robot manipulator controller, to autonomously perform the cutting operation from the output of the first action. Moreover, the effect of robotized pruning on grapevine physiology will be evaluated by monitoring whole-canopy real-time gas-exchange on a seasonal base. Therefore, robot and plant performance will be characterized in several parcels varying in terms of soil conditions (bare soil vs grassed), slope (flat vs steep versant), plant growth (high vs low vigor), and cultural facilities (pre-pruning vs control vines).
FinTech Milano, 2020 - 2023 The research focuses on FinTech that is the application of cutting-hedge digital technologies to improve financial activities . constantly addressed FinTech highlighting both its opportunities and threats for different interests, such as that of financial stability, consumer protection, financial innovation, etc. Both its newness and this lack of regulation encouraged centers of applied research, consultancy companies and the academia to contribute animatedly to the FinTech debate. For all these reasons, the research aims at studying FinTech, understanding the use of digital technologies in financial activities as well as its economic effects on all involved stakeholders and assessing which regulatory strategy best fits with it. Such "enabling technologies" are: digital platforms; big data; cloud computing; automating algorithms and distributed ledger technology (DLT). Distributed ledger technology (DLT) is a decentralized transaction and data management technology that leverages computer protocols to replicate the same ledger and update it without the need for a central responsible entity. Properly balancing different interests, such regulation can help the correct development of FinTech and turn out to be extremely effective for increasing the financial inclusion of the European Small Medium Enterprises (SMEs).
Home Progetti Finanziatori nazionali Textual Data and Tools for Coreference Resolution of Latin Publications Publications Questa pagina conterrà le pubblicazioni e i materiali prodotti durante lo svolgimento del progetto.
Lyric poetry books in the early modern Italy: digital archives and new editorial practices
Home Progetti Finanziatori nazionali Lyric poetry books in the early modern Italy: digital archives and new editorial practices. Lyric poetry books in the early modern Italy: digital archives and new editorial practices Brescia, 2020 - 2020 Sede: Brescia Area Scientifica: Responsabile scientifico: Prof. Andrea Canova Periodo di svolgimento della ricerca: 2020 - 2020 #faculty of arts and philosophy.
Home Progetti Finanziatori nazionali Identification of molecular mechanisms of coronary instability in homogeneous subsets of patients with acute coronary syndromes for the implementation of precision medicine (PRECISION Study). In patients presenting plaque rupture and systemic evidence of inflammation, the high frequency of aggressive T-cells and the reduced number and function of regulatory T-cells suggest that coronary instability might be related to still unknown mechanisms involving adaptive immunity. On the other hand, in a sizeable subset of patients, acute coronary events occur without increase in high sensitive C-reactive protein (hs-CRP) levels, a non-specific but sensitive marker of inflammation. In these patients, other mechanisms, including emotional and physical stress, probably play a pathogenic role, involving sympathetic nervous system activation and catecholamine release that, in turn, might lead to coronary vasoconstriction and favor vulnerable plaques fissure, platelet activation and hypercoagulability. The distinction of coronary artery thrombosis caused by plaque rupture into cases with or without signs of concomitant inflammation may have substantial therapeutic implications, as direct anti-inflammatory interventions for atherosclerosis emerge. An intense immunostaining pattern for hyaluronan and its receptor, CD44, has been reported along the plaque/thrombus interface in eroded plaque but not in fissured or stable plaque. Recent studies proposed a model of plaque erosion in which the endothelial shear stress and the consequent activation of Toll-Like Receptors (TLRs) might promote molecular pathways leading to plaque instability.
