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Modulation of EGFR signalling by cross-talk with other membrane receptor pathways
Home Progetti Finanziatori nazionali Modulation of EGFR signalling by cross-talk with other membrane receptor pathways. Modulation of EGFR signalling by cross-talk with other membrane receptor pathways Roma, 2019 - 2023 Epidermal Growth Factor Receptor (EGFR) is a cell surface protein with tyrosine kinase activity, and a major effector of extracellular signals promoting cell growth and survival, as well as tissue differentiation and homeostasis. EGFR is also considered a proto-oncogene, since its aberrant/constitutive activation is responsible for cancer cell growth and invasive properties; furthermore, its upregulation leads to resistance to targeted therapies in human solid tumors. Prompted by these preliminary data, in this project we aim at elucidating novel mechanisms regulating EGFR signaling, via the cross-talk with other membrane receptor pathways, such as inflammatory cytokines, or the Neuropilins and their extracellular ligands, including circulating miRNAs. Notably, secreted miRNAs circulating in body fluids may be captured and internalized by cell surface receptors, such as NRP1, and we will study whether such mechanism can effectively regulate mRNA transcripts encoding EGFR or other components of this pathway. Moreover, since NRP1 and NRP2 cell surface receptors have been found to regulate EGFR expression and signaling, their combined targeting with inhibitors and extracellular ligands could improve the efficacy of EGFR inhibitors in cancer treatment and prevent the onset of drug-resistance, as recently validated in our preliminary studies. In sum, we aim at the characterization of novel mechanisms controlling the EGFR pathway, via the cross-talk with other membrane receptors and their extracellular ligands.
Il suo obiettivo è quello di contribuire a incrementare la conoscenza e la discussione in merito a un livello di annotazione metalinguistica che trova poco spazio nelle ricerche sulle risorse linguistiche e sulla trattazione automatica del linguaggio applicate al latino. Il progetto prevede due fasi operative : Nella prima fase, si delineano le linee guida dell'annotazione, si individua lo strumento di annotazione e si procede con l'annotazione dei testi latini selezionati. Vengono utilizzati testi latini già arricchiti con lemmatizzazione e Part-of-Speech (PoS)-tagging e collegati alla LiLa Knowledge Base , una raccolta di molteplici risorse linguistiche per il latino descritte con lo stesso vocabolario di conoscenza e interconnesse secondo i principi del paradigma Linked Data ( https://lila-erc.eu/#page-top ). Segue l'elenco dei corpora dei testi che si prevede di arricchire con l'annotazione di coreferenza nell'ambito di questo progetto: Latino classico . I dati sono tratti dal corpus LASLA ( http://web.philo.ulg.ac.be/lasla/textes-latins-traites/ ), un'ampia raccolta di circa 1,7 milioni di parole provenienti da oltre 130 testi classici e tardo-latini lemmatizzati e contrassegnati morfologicamente. I dati di partenza sono stati resi liberamente disponibili sul repository del laboratorio LASLA prima dell'inizio di questo progetto e sono accessibili attraverso la LiLa Knowledge Base all'indirizzo https://lila-erc.eu/data/corpora/Lasla/id/corpus . I dati sono tratti dal corpus Computational Historical Semantics Corpus ( http://lila-erc.eu/data/corpora/CompHistSem/id/corpus ), un progetto cooperativo che coinvolge le università di Bielefeld, Francoforte, Ratisbona e Tubinga.
Home Progetti Finanziatori nazionali Textual Data and Tools for Coreference Resolution of Latin Data Data.
Lotta alla povertà: ricerca empirica in supporto delle politiche pubbliche
Home Progetti Ateneo Lotta alla povertà: ricerca empirica in supporto delle politiche pubbliche. Queste finalità saranno perseguite valorizzando al meglio le risorse e competenze presenti all'interno del team di ricercatori del progetto. Alle competenze di carattere economico (a loro volta riferite ad un ventaglio di specializzazioni), il team di ricercatori coniuga un ampio spettro di competenze in chiave multidisciplinare, da quelle giuridiche, a quelle sociologiche e demografiche, a quelle psico-pedagogiche. Inoltre il team è arricchito dalla presenza di ricercatori esterni di altissimo profilo. Anzitutto, il comitato di indirizzo, che include alcuni tra i massimi esperti a livello mondiale sulle tematiche di rilievo. A questo si affiancano in veste più operativa ricercatori delle istituzioni internazionali (in particolare Banca Mondiale e OCSE) che sono attivi nello sviluppo di politiche anti-povertà e anti-diseguaglianza. Ulteriore aspetto caratterizzante è la presenza significativa di finanziamenti nazionali ed internazionali esterni al progetto che ne valorizzano in modo sostanziale la capacità operativa, l'internazionalizzazione e l'impatto sulle politiche pubbliche.
Ricerca Progetti Pubblicazioni Strutture Valorizzazione Evidenze La ricerca Mission e
Home Progetti Ateneo (Im)perfetti Sconosciuti Gruppo di lavoro Gruppo di lavoro L’equipe di ricerca è composta da ricercatori afferenti a otto diverse Facoltà dell’Università Cattolica del Sacro Cuore, tre sedi (Milano, Brescia e Roma) e 13 raggruppamenti scientifico-disciplinari, due docenti a contratto, due assegnisti di ricerca e due specializzandi. Alla progettazione delle attività e alla discussione dei risultati intermedi parteciperanno anche i componenti di un Comitato Internazionale di Esperti. Il progetto è diretto da Laura ZANFRINI, assistita da Emma GARAVAGLIA e Lorenza A. LORENZETTI.
Home Progetti Ateneo Comunicare la scienza. Mediazione e mediatori del sapere scientifico nella società complessa.
Cultures of sovereignty, transformations of democracy and dynamics of power in the global age
Home Progetti Finanziatori nazionali Cultures of sovereignty, transformations of democracy and dynamics of power in the global age. Cultures of sovereignty, transformations of democracy and dynamics of power in the global age Milano, 2020 - 2023 During the last three decades in the human and social sciences, the processes identified as «globalization» has often been considered as the main cause of the crisis of the «sovereignty». Regardless of the results to which they came, many readings dedicated to the role of states, to their crisis or their survival, tend to proceed from a ‘monolithic’ view of «sovereignty», predominantly built on the model of the modern European state. In this sense, it would be essential to recognize different «cultures» of sovereignty, so like certain representations of reality, internalized (in different levels) by the actors, who establish criteria with which states interpret the international community and their own ‘material’ interests, and from which specific behaviors arise. The present research project intends to move within this image of sovereignty , with the aim of reconstructing the transformations in the cultures of sovereignty. Gruppo di lavoro: Silvio Cotellessa - Faculty of Political and Social Sciences Chiara Continisio - Faculty of Education Luca Pietro Azzaro - Faculty of Political and Social Sciences Partner: Università Cattolica del Sacro Cuore (Coordinator); Università degli Studi di Padova; Università degli Studi di Bologna; Università degli Studi di Salerno. Sede: Milano Area Scientifica: scienze politiche e sociali Responsabile scientifico: Prof. Damiano Palano Periodo di svolgimento della ricerca: 2020 - 2023 #sovereignty #governance #democracy #state #power #governmentality #prin #faculty of political and social sciences.
Home Progetti Finanziatori nazionali Textual Data and Tools for Coreference Resolution of Latin People People Unità Milano - Univerità Cattolica del Sacro Cuore Prof. Marco Carlo Passarotti (Principal Investigator) Dott. Paolo Ruffolo Dott.ssa Roberta Grazia Leotta Unità Udine - Università degli Studi di Udine Prof. Renato Oniga Dott.ssa Eleonora Delfino.
Home Progetti Finanziatori UE Harmful Traditions. Harmful Traditions Milano, 2020 - 2025 Harmful traditions (e.g. child marriage, female genital cutting (FGC), breast ironing) affect millions of girls in developing countries. These customs have a strong detrimental effect on women’s human capital accumulation, empowerment and wellbeing, thus perpetuating gender imbalance and the vicious circle of poverty. She will then examine whether contemporaneous factors , and in particular current political institutions , play a role in perpetuating harmful norms, manipulating the timing of FGC to influence electoral outcomes. Finally, using climate data, she will provide new insights on the relationship between global warming and child marriage. To answer to the second question, she proposes three randomized control trials uniquely designed to address specific determinants of the persistence of harmful traditions: alternative harmless rituals to remove cultural barriers, information provision to reduce breast ironing, peers’ interactions to decrease FGC and child marriage. See also : https://www.cattolicanews.it/un-erc-alla-cattolica-per-combattere-le-norme-sociali-dannose-per-le-donne Sede: Milano Area Scientifica: scienze economiche e statistiche Responsabile scientifico: Prof.ssa Lucia Corno Periodo di svolgimento della ricerca: 2020 - 2025 #gender #women #inequalities #development countries #health #political economics #erc #faculty of economics.
Home Progetti Finanziatori internazionali The Internet of Toys. The Internet of Toys Milano, 2018 - 2021 This project will investigate the emerging communication world of the Internet of Toys where toys relate one-on-one to children and also connect to other toys, other children and/or database data. Engaging in future oriented research, this national and international research project will examine the emerging benefits and risks of these connected toys through engaging with families and industry, as well as with regulatory and policy developments. The research will inform and influence policy makers, toy designers and families of children too young to understand the implications of these toys in terms of data privacy and security. It will benefit decision-making regarding the design and regulatory environments in which these toys are made.
Winter pruning impacts for the 20-35% of the yearly labor demand that can be lowered by introducing mechanical operations when spur-pruning is adopted. Despite agricultural solutions have been developed in recent years, robotics in viticulture is still bursting, and only a few prototypes have been described for performing winter spur-pruning; at present engineering processes seem to be ongoing whilst interactions with grapevine physiology were never assessed. The first action will provide hierarchical guidelines for a translation of the human cognition process into algorithms for automated plant recognition, and robotized pruning. Multiple combinations of integrated general rules driving winter pruning process with specifically conceived case studies will compose a dedicated database for developing multi-modal sensing system for recognition of grapevine architecture and identification of target regions and cutting points. The second action will integrate off-the-shelf electric shears into a commercial robot manipulator controller, to autonomously perform the cutting operation from the output of the first action. Moreover, the effect of robotized pruning on grapevine physiology will be evaluated by monitoring whole-canopy real-time gas-exchange on a seasonal base. Therefore, robot and plant performance will be characterized in several parcels varying in terms of soil conditions (bare soil vs grassed), slope (flat vs steep versant), plant growth (high vs low vigor), and cultural facilities (pre-pruning vs control vines).
Home Progetti Ateneo Comunicare la scienza. Mediazione e mediatori del sapere scientifico nella società complessa. Risultati Risultati Eventi Pubblicazioni e partecipazioni a congressi.
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Ricerca Progetti Pubblicazioni Strutture Valorizzazione Evidenze La ricerca Mission e
Popularitas Milano, 2018 - 2020 The Popularitas project aims to provide a comprehensive study of the precedents of populism in ancient Rome . The Latin adjective “popularis” had a passive meaning (the man who enjoys the favour of the people), but also an active one (the man who seeks the favour of the people). The Popularitas project will historicize for the first time a much-discussed political phenomenon of our time and highlight similarities (and differences) with the ancient political practice. It will provide the tools for a diachronic assessment of modern populism, opening new research prospects . Its ambition is not only to be useful to the historians of the ancient world, but also to offer to political scientists and sociologist some fresh material and a new starting point for a proper understanding of the phenomenon. Working group : Giuseppe Zecchini – Faculty of Arts and Philosophy Gianpaolo Urso Sede: Milano Area Scientifica: scienze dell’antichità, filologico-letterarie e storico-artistiche Responsabile scientifico: Prof. Giuseppe Zecchini Periodo di svolgimento della ricerca: 2018 - 2020 #populism #consensus #ancient rome #history #msca-if #faculty of arts and philosophy.
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FinTech Milano, 2020 - 2023 The research focuses on FinTech that is the application of cutting-hedge digital technologies to improve financial activities . constantly addressed FinTech highlighting both its opportunities and threats for different interests, such as that of financial stability, consumer protection, financial innovation, etc. Both its newness and this lack of regulation encouraged centers of applied research, consultancy companies and the academia to contribute animatedly to the FinTech debate. For all these reasons, the research aims at studying FinTech, understanding the use of digital technologies in financial activities as well as its economic effects on all involved stakeholders and assessing which regulatory strategy best fits with it. Such "enabling technologies" are: digital platforms; big data; cloud computing; automating algorithms and distributed ledger technology (DLT). Distributed ledger technology (DLT) is a decentralized transaction and data management technology that leverages computer protocols to replicate the same ledger and update it without the need for a central responsible entity. Properly balancing different interests, such regulation can help the correct development of FinTech and turn out to be extremely effective for increasing the financial inclusion of the European Small Medium Enterprises (SMEs).
Home Progetti Ateneo Comunicare la scienza. Mediazione e mediatori del sapere scientifico nella società complessa.
Home Progetti Ateneo Comunicare la scienza. Mediazione e mediatori del sapere scientifico nella società complessa. Contatti Contatti Per informazioni o domande sul progetto, scrivere a ricerca.comunicarelascienza@unicatt.it.
La pandemia come rischio globale. Quali strategie contro Covid-19?
Home Progetti Ateneo La pandemia come rischio globale.
PROTON Milano, 2016 - 2019 PROTON aims at improving existing knowledge on the processes of recruitment to organised crime and terrorist networks (OCTN) through an innovative integration between social and computational sciences. To achieve its aim, PROTON will complete three specific objectives: Investigate the social, psychological and economic factors leading to OCTN, including their connection with cybercrime and the cyberspace. The factors will be transformed into input for PROTON’s final outputs, PROTON-S and PROTON Wizard, designed for helping policy makers to act more effectively against OCTN; Develop PROTON-S, agent-based modelling (ABM) simulations of the effects of different societal and environmental changes on OCTN. PROTON-S will generate virtual societies in a computer laboratory, enabling to test the impact of different scenarios on the evolution of, and particularly individuals’ recruitment to, OCTN; Develop PROTON Wizard , a user-friendly software tool embedding the results of the ABM simulations. PROTON’s impact will improve the quality of prevention policies on OCTN, providing at the same time significant innovations in the social, technological and computational sciences . PROTON-S, based on simulations, will bear no ethical and societal risks, and will create a breakthrough in the understanding of OCTN, enabling better policies and stimulating further innovation. PROTON Wizard will provide the first support tool for policy makers at the international, national and local level, giving easy access to the most advanced scientific research .
Home Progetti Finanziatori UE Finanziatori UE.
A Mindful Community for People with ALS and their Primary Caregivers
Home Progetti Finanziatori internazionali A Mindful Community for People with ALS and their Primary Caregivers. A Mindful Community for People with ALS and their Primary Caregivers Milano, 2020 - 2021 The primary aims of this project are two-fold: to develop a “mindful” online community of people with ALS and their caregivers, and to test its efficacy in the improvement of their quality of life. The study is built upon previous research by this study team testing an online mindfulness intervention for people with ALS and their caregivers, as well as research about the positive impact that mindfulness has on the ALS community. In this study, ALS patients and caregivers will first complete an online mindfulness training program. The social sharing platform will be characterized by prompts and suggestions to encourage the participants to apply and share “mindful knowledge” in the form of reflections, creative problem-solving, and positive engagement. The primary hypothesis for this study is that the active participation of a newly created “mindful community” will have a positive effect on the participants’ well-being in comparison to an active control group. (Coordinator) Università Cattolica del Sacro Cuore - Italy Sede: Milano Area Scientifica: scienze psicologiche Responsabile scientifico: Prof. Francesco Pagnini Periodo di svolgimento della ricerca: 2020 - 2021 #als #amyotrophic lateral sclerosis #community #social #mindful #faculty of psychology.
Home Progetti Finanziatori nazionali Textual Data and Tools for Coreference Resolution of Latin Publications Publications Questa pagina conterrà le pubblicazioni e i materiali prodotti durante lo svolgimento del progetto.
